Applied Statistics 2010
International Conference

September 19 - 22, 2010
Ribno (Bled), Slovenia

Next conference:
Applied Statistics 2011
September 25 - 28, 2011

Past conferences:
Applied Statistics 2009
Applied Statistics 2008
Applied Statistics 2007

Applied Statistics 2006
Applied Statistics 2005
Applied Statistics 2004
Conferences before 2004



  Important dates

  Acceptance note
     June 15
  Registration and
  hotel reservation
      July 1
  Reduced early
  payment fee
      July 15


Slovenian Research Agency (ARRS)



Three-sided Hypothesis Testing: Simultaneous Testing of Superiority, Equivalence and Inferiority

Jelle Goeman
Leiden University Medical Center, Netherlands

We propose three-sided testing, a testing framework for simultaneous testing of inferiority, equivalence and superiority in clinical trials, controlling for multiple testing using the partitioning principle. Like the usual two-sided testing approach, this approach is completely symmetric in the two treatments compared. Still, because the hypotheses of inferiority and superiority are tested with one-sided tests, the proposed approach has more power than the two-sided approach to infer non-inferiority or non-superiority. Applied to the classical point null hypothesis of equivalence, the three sided testing approach shows that it is sometimes possible to make an inference on the sign of the parameter of interest, even when the null hypothesis itself could not be rejected. Relationships with confidence intervals are explored, and the effectiveness of the three-sided testing approach is demonstrated in a number of recent clinical trials.

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